Collaborative Research Projects between The Kaplan Medical Center
and The Weizmann Institute of Science
The medical team at the Kaplan Medical Center and the scientists of the Weizmann Institute have for many years maintained a direct and friendly relationship which have included various scientific developments, research and sharing of information. Many specialists from the KMC frequently visit the Weizmann Institute and take part in scientific studies and simultaneously disseminate the study’s results, benefiting both institutions.
Recently, various community-oriented, collaborative projects were initiated. Such projects immensely enrich medical knowledge vis-à-vis research and theoretical science and have been proven immensely fruitful for both the medical world (the hospital) and the academic one (Weizmann). Following are a number of exceptionally successful collaborative projects, which have contributed to the warm and friendly relationship between the two academic institutions:
- A special “Health Day” was declared. It brought together Kaplan specialists and the scientists and managers of the Weizmann Institute of Science. Hundreds of employees and scientists received a medical examination and were provided with relevant medical information. The event took place in a gigantic “Health Tent” which was situated on the vast green lawn of the Weizmann Institute.The Weizmann’s scientists underwent a variety of medical tests by the KMC’s specialists, including: Intraocular Pressure, blood pressure, respiratory examinations, breast examination and skin conditions. In addition, scientists and local employees received information regarding nutrition facts, healthy eating habits and methods of keeping healthy and safe work and domestic environments.Interactive conferences were held on the subject of the correlation between health and science and included many local scientists and physicians from the KMC. Prof. Yaron Cohen from the Weizmann Institute and KMC’s Prof. Hila Knobler and Dr. Simona Naor spoke of the immune system and metabolic diseases. Prof. Hadassah Degani of Weizmann Institute and KMC’s Dr. Noa Ben Baruch spoke of the innovations in breast medicine.
Prof. Ada Yonat, winner of the Nobel Prize in Chemistry 2009, during physical examinations on Health Day at the Weizmann Institute of Science
- A panel of specialists from the Weizmann Institute of Science and the Kaplan Medical Center discussed joint interests such as scientific developments in cancer, diabetes and metabolic illnesses.
- Weizmann at KMC’s inpatients pediatric ward: a unique activity in which a mobile lab from the Davidson Institute was brought into the pediatric inpatient ward at the Kaplan Medical Center with the objective of providing hospitalized children with useful scientific information combined with some amusement. “Dr. Weizmann’s Kitchen” engaged the children in various activities such as: scientific uses of red cabbage, trying to fry an egg with liquid nitrogen, trying to break an egg by squeezing its extremities.We discussed facts that keep a diet Cola can afloat while a regular Cola can sinks, and we ended this fine day of science with a special type of ice cream which was made without a refrigerator and had no sugar or dairy in it so all children could enjoy! Ms. Osnat Segev, manager of the educational center at the pediatric inpatient ward at KMC said: “The children enjoyed every minute, they were curious and asked lots of questions, they were happy to take part in experiments and assisted in the various scientific cooking.”
“Dr. Weizmann’s Kitchen” in the Pediatric inpatient Ward at the Kaplan Medical Center
COLLABORATIVE RESEARCH OF THE WEIZMANN INSTITUTE OF SCIENCE
AND THE KAPLAN MEDICAL CENTER
- With Prof. Edna Moses – KMC’s Immunology Department
- Beneficial effects of the anti estrogen tamoxifen on systemic lupus erythematosus of [NZBxNZW] F1 female mice are associated with specific reduction of IgG3 autoantibodies.
- Lupus manifestations in severe combined immunodeficient [SCID] mice and in Human/Mouse radiation chimeras.
- Immunomodulation by a dual altered pepide ligand (APL) of autoreactive responses to the acetylecholine receptor of peripheral blood lymphcytes of patients with myasthenia gravis.
- Amelioration of lupus manifestations by a peptide based on the complementarily determining region 1 of an autoantibody in severe combined immunodeficient (SCID) mice engrafted with peripheral blood lymphocytes of systemic lupus erythematosus (SLE) patient.
- Autoantibodies to a NR2A peptide of the glutamate/NMDA receptor in sera of patients with systemic lupus erythematosus.
- High prevalence of systemic lupus erythematosus in 78 myasthenia gravis patients: A clinical and serologic study.
- Peptide based on the complementarity-determining region 1 of an autoantibody ameliorates lupus by up-regulating CD4+CD25+ cells and TGF.
- Clinical amelioration of murine lupus by a peptide based on the complementarity determining region-1 of an autoantibody and by cyclophosphamide: Similarities and differences in the mechanisms of action.
- The tolerogenic peptide, hCDR1, down-regulates pathogenic cytokines and apoptosis and upregulates immunosuppressive molecules and regulatory T- cells in peripheral blood mononuclear cells of lupus patients.
- Treatment of lupus patients with a tolerogenic peptide, hCDR1 (Edratide): Immunomodulation of gene expression.
- Tolerogenic peptide that induces suppressor of cytokine signaling (SOCS)-1 restores the aberrant control of IFN-g signaling in lupus-afflicted (NZBxNZW) F1 mice.
- With Prof. D. Novick and Prof. M. Rubinstein – the KMC’s Virology Department
- Elevated levels of Interleukin-18 and Interleukin-18 Binding protein in the sera of patients with Wegener’s Granulomatosis.
- High circulating levels of free Interleukin-18 in patients with active SLE In the presence of elevated levels of Interleukin-18 binding protein.
- Prof. Daniel Zaitman, President of the Weizmann Institute and Prof. Bernardo Senior at the Weizmann Institute, formerly chief of KMC heart surgery department, with Prof. J. Yahav at the dedication of the new IDA CABAKOFF CHILDREN’S MEDICAL CENTER at KAPLAN MEDICAL CENTER.
Right- Prof. Daniel Zaifman, President of theWeizmann Institute, Prof.J.Yahav, Prof. Bernardo Vidana